Transcription factor Nrf‐2 regulates the expression of GPX4 and SLC7A11genes that govern redox homeostasis and ferroptosis sensitivity.[14, 15] We found that in the mouse cerebral cortex, the expression of Nrf‐2 in neurons is extremely low under both non‐ischemia and ischemia conditions; in contrast, it has a certain expression in astrocytes of sham mice, and its expression was significantly increased in reactive astrocytes in the peri‐infarct area of mice 14 d post‐I/R (Figure 2c). The gene discussed is GPX4; the disease is ischemia.