During the subacute phase of ischemic stroke, the immunohistochemical results showed that the immunostaining of TfR1 in reactive astrocytes was increased from d 3 to d 14 post‐I/R and reached the peak at d 14 after I/R (Figure 5b; Figure S7b, Supporting Information), accompanied by a large amount of iron deposition (Figure 3e). The gene discussed is TFRC; the disease is ischemic stroke.