These results suggest that low expression of Nrf‐2 in neurons and its decrease after ischemic stroke are associated with the reduction of the expressions of GPX4 and SLC7A11, resulting in neuronal ferroptosis; in contrast, higher expression of Nrf‐2 in astrocytes and its increase after ischemic stroke promote the expressions of GPX4 and SLC7A11, thus enhancing astrocytes resistance to ferroptosis, leading to astrogliosis. This evidence concerns the gene SLC7A11 and ischemic stroke.