GPX4 and ischemia: This study identifies iron overload‐mediated similar oxidative stress changes but opposite expressive patterns in endogenous antioxidant defense systems of Nrf‐2/GPX4 and SLC7A11 between neurons and astrocytes as a central mechanism, causing divergent ferroptotic outcomes with neurons being more vulnerable to ferroptosis, while astrocytes display greater resistance in ischemia/reperfusion insults.