Some studies have reported that dysregulation of TfR1 palmitoylation affects the Tf‐TfR1 cycle, leading to cellular iron overload in neurodegenerative diseases.[30, 31] However, how palmitoylation of TfR1 causes iron overload in reactive astrocytes induced by ischemic stroke is still unclear. The gene discussed is TFRC; the disease is ischemic stroke.