Recently, a study identified downregulation of DHHC5‐mediated TfR1 palmitoylation in oligodendrocytes is related to neonatal sevoflurane exposures‐associated neurotoxicity.[62] How DHHC5‐mediated palmitoylation of TfR1 in astrocytes participates in ischemic stroke‐induced iron overload and brain damage remains to be investigated in the very near future. The gene discussed is ZDHHC5; the disease is ischemic stroke.