Recently, a study identified downregulation of DHHC5‐mediated TfR1 palmitoylation in oligodendrocytes is related to neonatal sevoflurane exposures‐associated neurotoxicity.[62] How DHHC5‐mediated palmitoylation of TfR1 in astrocytes participates in ischemic stroke‐induced iron overload and brain damage remains to be investigated in the very near future. Here, ZDHHC5 is linked to Tangier disease.