HAMP and ischemic stroke: Hepcidin can inhibit the iron absorption of intestinal epithelium and the recycling of iron from aging red blood cells through macrophages, thus resulting in reducing the level of iron in blood.[48] To further investigate the effects of alleviating iron overload on ischemic stroke, we generated a double transgenic mouse line to conditionally overexpress the liver Hamp, as a model of low iron content in peripheral blood circulation.