In addition to these classical pathways, studies have found that Piezo1 interacts with the Hippo-YAP/TAZ pathway, enhancing fibrosis and ECM deposition, ultimately accelerating myocardial remodeling and the onset of heart failure (Jiang F. et al., 2021; Sun et al., 2024; Beech and Kalli, 2019). The gene discussed is PIEZO1; the disease is heart failure.