PIEZO1 and obesity due to melanocortin 4 receptor deficiency: When Piezo1 function is impaired, metabolic dysregulation of adipocytes may lead to obesity and metabolic syndrome, suggesting that Piezo1 plays a potential pathological role in the development of metabolic diseases (Rendon et al., 2022; Byun et al., 2024; Catalán et al., 2024).