This suggests that Piezo1 not only participates in basic intestinal physiological functions but may also play a regulatory role in the development of metabolic diseases, such as obesity and type 2 diabetes (Zhu W. et al., 2022; Jacobs et al., 2024; Li Y. et al., 2024). The gene discussed is PIEZO1; the disease is obesity due to melanocortin 4 receptor deficiency.