Second, SOD1 and catalase may require longer or more intense training stimuli to adapt: Baasch et al. observed no change in these proteins after 10 weeks of HIIT (Baasch-Skytte et al., 2021), while Brinkmann et al. also reported no catalase adaptation after 3 months of moderate training, suggesting inherent insensitivity of these cytosolic enzymes to exercise in T2DM (Brinkmann et al., 2012). This evidence concerns the gene CAT and type 2 diabetes mellitus.