Fatone et al. found 1-year combined aerobic-resistance exercise (2 sessions/week, 140 min/session: aerobic 55%–70% VO2max, resistance 60%–80% 1RM) significantly upregulated T2DM patients’ skeletal muscle PPARγ mRNA at 6 months and PPARα mRNA at 6/12 months (Fatone et al., 2010). Here, PPARG is linked to type 2 diabetes mellitus.