Brinkmann et al. showed that after 3 months of twice-weekly moderate exercise (either endurance or resistance training), the T2DM group had significant increases in skeletal muscle SOD2, GPX1, and PRDX5 expressions, which reached 165.9%, 162.4%, and 137.5% of pre-training levels respectively (p < 0.05), with no training modality-specific effects observed (Brinkmann et al., 2012). This evidence concerns the gene SOD2 and type 2 diabetes mellitus.