PPARA and type 2 diabetes mellitus: This PPARG-mediated biogenic effect is further validated by Fatone et al. (Shaw et al., 2011), who found 1-year combined training upregulated PPARγ mRNA at 6 months and PPARα mRNA at 6/12 months in T2DM—consistent with the trend of mitochondrial content elevation observed in subgroup analyses (Fatone et al., 2010).