The 12-week HIIT (3 sessions/week) led to sustained p-PARKIN elevation in T2DM populations even after 4 weeks of detraining, whereas shorter-duration HIIT (2 weeks, 4 sessions/week, 21 min/session at 80% HRmax) failed to induce persistent autophagic adaptations in T2DM (Dela et al., 2019). Here, PRKN is linked to type 2 diabetes mellitus.