MFN2 and type 2 diabetes mellitus: Mastrototaro et al. found 12-week HIIT increased T2DM’s MFN2 and reduced p-DRP1/DRP1 ratio; after 4-week detraining, these HIIT-induced changes (elevated MFN2, lowered p-DRP1/DRP1) were sustained in the T2DM group (Mastrototaro et al., 2024).