NRF1 and type 2 diabetes mellitus: In specific included studies, Mogensen et al. reported that 10 weeks of aerobic training (∼65% VO2peak) significantly increased PPARG expression in T2DM (PPARA unchanged), which drives mitochondrial biogenesis by activating PGC-1α, NRF-1, and TFAM to coordinate mtDNA and nuclear DNA transcription (Hey-Mogensen et al., 2010).