OPA1 and type 2 diabetes mellitus: In contrast, other exercise regimens failed to induce such changes: 10 weeks of 10–20-30 training (3 sessions per week, 17 min per session, 82% ± 5% HRmax) had no significant effect on MFN1, OPA1 or total DRP1 in T2DM skeletal muscle (Baasch-Skytte et al., 2021).