Thus, low level chronic inflammation may synergize with other changes in the ocular environment including other ocular surgeries, transient uveitis, onset of age-related macular degeneration, or vitreous degeneration leading to release of stored TGFβ or other growth factors, diabetes etc. to “activate” quiescent LECs or myofibroblasts to seek weaknesses in the IOL-capsular barrier, leading to late onset PCO. The gene discussed is TGFB1; the disease is uveitis.