HSPA5 and nonpapillary renal cell carcinoma: Moreover, Song et al. discovered that miR-30c-5p in urinary extracellular vesicles targets heat shock protein 5 (HSPA5) and inhibits ccRCC progression, exhibiting a sensitivity of 68.57% and specificity of 100%, demonstrating significant potential as a diagnostic biomarker for ccRCC (Song et al., 2019).