GPER1 and Gastric Metaplasia: Bypassing conventional Cre-based constructs, his team crossed TetO-Cre mice with Gpr30-rtTA mice to specifically label GPR30+ chief cells, coupled with fluorescent reporter gene (R26-TdTomato) tracking, thereby proposing GPR30 - a G protein-coupled estrogen receptor - as a novel chief cell marker.The researchers induced gastric metaplasia through high-dose tamoxifen, DMP-777, and H. pylori infection, while establishing Kras(G12D) and HRAS(G12V) mutant mouse models.