Resistance mechanisms usually involve deregulation of proteins involved in the intrinsic apoptosis pathway, including members of the Bcl-2 family and the p53 tumor suppressor, overexpression of inhibitors of apoptosis proteins (IAPs), or overactivation of signaling pathways such as PI3K/AKT, even in the presence of DNA damage (19). This evidence concerns the gene AKT1 and neoplasm.