Furthermore, multivariate logistic regression analysis indicated that elevated UA (OR: 2.73, 95%CI: 1.399-5.328, P = 0.003), elevated NLR (OR: 6.42, 95%CI: 3.914-10.532, P < 0.001) and elevated CEA (OR: 2.365, 95%CI: 1.423-3.93, P = 0.001) were independent risk factors for colorectal cancer bone metastasis (Table 6). The gene discussed is CEACAM5; the disease is metastasis.