EGFR and colorectal carcinoma: In vitro and in vivo studies show that these plant-derived compounds can modulate multiple biochemical pathways involved in CRC development, including Wnt/β-catenin, MAPK, PI3K/Akt, Akt/mTOR, EGFR/STAT/ERK, and NF-κB pathways [4, 18, 39–41].