At present, although studies have revealed the clinical significance of some common fusion genes such as ETV6/RUNX1 and BCR/ABL, there is still a lack of systematic and in-depth research on Chinese children regarding the distribution characteristics of rare fusion genes, Ph-like ALL-related molecular abnormalities, and their associations with epigenetic modifications and dynamic changes of minimal residual disease (MRD). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.