A clinical follow-up was conducted on 137 B-ALL children with positive genes (59 cases of ETV6/RUNX1 positivity, 22 cases of E2A/PBX1 positivity, 25 cases of MLL positivity, and 19 cases of BCR/ABL positivity) among 302 children with acute lymphoblastic leukemia. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.