Clinical correlation analysis showed that the initial white blood cell count of children with Ph-like ALL was 98.64 ± 32.15 × 109/L, significantly higher than that in the ETV6/RUNX1-positive group (P < 0.01); additionally, 71.4% (20/28) of these children showed poor early response to prednisone, consistent with the clinical manifestation of a high-risk phenotype. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.