Notably, the authors emphasized that ETV6::RUNX1 and BCR::ABL1 are both founder leukemogenic events in pediatric BCP-ALL (accounting for 20%–25% and 2%–3% of cases, respectively), and their coexistence had only been reported in one pediatric and one young adult case before this study. Here, RUNX1 is linked to acute lymphoblastic leukemia.