First, in a cohort of 302 newly diagnosed Chinese children with ALL, it is the first time to comprehensively integrate detection data of common fusion genes, rare fusion genes such as ZNF384 rearrangement and DUX4 rearrangement, and Ph-like ALL-related molecules such as CRLF2 rearrangement and JAK2 mutation. Here, CRLF2 is linked to acute lymphoblastic leukemia.