SOX-10, a transcription factor that plays an important role in melanocytic development but is not expressed in dendritic cells, is notably a sensitive diagnostic indicator of nodal melanoma metastasis and has especially improved the identification of micrometastasis compared with other widely used immunostains, such as S100, Melan-A/MART-1, and HMB-45 [14, 16, 17]. The gene discussed is MLANA; the disease is melanoma.