Regarding inflammatory factors, the analysis results showed that dexmedetomidine significantly reduced interleukin-6 (IL-6) [standardized mean difference (SMD) = 0.04, 95% confidence interval (95%CI) = (−0.11, 0.19), p = 0.574] and tumor necrosis factor-α (TNF-α) levels [SMD = −2.39, 95, 95%CI = (−3.52, −1.27), p < 0.001] in sepsis patients, while exerting no effect on C-reactive protein (CRP) levels. This evidence concerns the gene IL6 and Sepsis.