While LBP responds to invasive bacterial infection and presents LPS to important cell-surface pattern recognition receptors called CD14 and TLR4 (37), CRP binds to phosphocholine expressed on the surface of damaged cells, as well as to the polysaccharides and peptosaccharides present on bacteria, and helps to promote phagocytosis and the innate immune response against foreign infectious pathogens (38, 39). Here, TLR4 is linked to bacterial infectious disease.