Although further studies are required to better understand the mechanism of lesion development in Adipoq-Cre;GsαR201C mice, these data strongly suggest that Adipoq+ marrow stromal cells could be implicated in the pathogenesis of FD and other skeletal diseases with abnormally increased bone resorption such as, for example, hyperparathyroidism. This evidence concerns the gene ADIPOQ and Fabry disease.