The mechanisms by which obesity leads to hypertension are multifaceted, involving overactivation of the sympathetic nervous system,25 stimulation of the renin‐angiotensin‐aldosterone system,26 dysregulation of adipose‐derived cytokines,27 insulin resistance,28 and structural as well as functional changes in the kidneys.29 The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.