Analyses correlating the changes in the Akt/mTOR/p70S6K signaling pathway with the pathological alterations in skeletal muscle of myotonic dystrophy type 1 (DM1) patients have revealed extensive activation of this pathway, which consequently leads to pathological hypertrophy of muscle fibers (17, 18). This evidence concerns the gene RPS6KB1 and myotonic dystrophy type 1.