To comprehensively investigate S100A10 expression patterns in cardiac hypertrophy, we analyzed three independent gene expression datasets (GSE5500, GSE116250, and GSE36961) comprising both murine models of transverse aortic constriction (TAC)-induced hypertrophy and human samples of dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM). This evidence concerns the gene S100A10 and familial dilated cardiomyopathy.