PAX3 and Werner syndrome: In a cohort of 90 WS probands, Wang et al. identified PAX3 variants in 13 individuals (14.4%; 13/90), three of which were de novo (c.668C>T, c.752T>C, and c.922dupG), accounting for 23.1% (3/13) of PAX3-positive cases (Wang et al., 2022).