CALR and neoplasm: IRE-induced apoptotic tumor cells leak a significant amount of immunogenic damage-associated molecular patterns (DAMPs) tumor antigens (TAs) and high mobility group protein B1 (HMGB1) along with chaperonins like heat shock protein 70 (HSP70) and calreticulin, which act collectively to stimulate dendritic cells (DCs) in IRE-ablated tumors (1–3).