Considering the reduced mass of tumor tissues and the less suppressive TME following IRE+Combo ablation, tumor-infiltrated CD8+CD103+TCF1+ TRM cells should exhibit prolonged survival, greater resistance to exhaustion and more cytotoxicity to tumor cells, leading to complete eradication of IRE+Combo-treated 3LLOVA lung cancer (Figure 9). Here, CD8A is linked to lung cancer.