To adjust for the above confounding factors, we used 1:4 PSM (covariates included: age, gender, BMI, smoking index, ECOG score, PDL1 status, TNM stage, diabetes, radiotherapy history, surgical history, ICIs treatment lines, maximum diameter of target lesion, metastasis site, etc.)to obtain 230 patients in the No BBs group and 88 in the BBs group. This evidence concerns the gene CD274 and diabetes mellitus.