At the same time, IH induces tumor cells to secrete interleukin-10 (IL-10), which in turn facilitates the polarization of TAMs towards the M2 phenotype (152), and also promotes the enrichment of immunosuppressive cell populations, including MDSCs, granulocytes, and Tregs, together creating a pro-tumor immune-suppressive microenvironment (153). This evidence concerns the gene IL10 and neoplasm.