Studies have shown that HLA-G interacts with inhibitory receptors such as immunoglobulin-like transcripts (ILT) 2 and ILT4 to inhibit immune-cell functions, including (a) antigen-presenting cell maturation; (b) natural killer (NK) cell and T-cell cytotoxicity, proliferation, and anti-tumor cytokine or chemokine production; (c) B-cell proliferation, antibody production, and chemotaxis; and (d) neutrophil phagocytosis and reactive oxygen species (ROS) production (6, 10). This evidence concerns the gene LILRB2 and neoplasm.