CD274 and cancer: Since then, other ICIs, such as programmed death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) antibodies, have provided promising alternative treatments for certain types of advanced cancer, although only a few patients benefit clinically because of primary or adaptive resistance and life-threatening immune-related adverse events (irAEs), such as in patients with colorectal cancer (CRC) (2–4).