HLA-G and cancer: These divergent observations could mainly be attributed to the fact that mAb 4H84-positive staining only indicates the total expression of all isoforms and cannot determine the individual profiles of the HLA-G1 to HLA-G7 isoforms or the degree of expression in cancer lesions for the detection of all α1 domain-retaining HLA-G isoforms (HLA-G1 to HLA-G7) (30).