In hCD19+ tumor-bearing mice, transferred hCD19-specific CAR T cells reveal that tumor-infiltrating CD8+ CAR+ and endogenous CD8+ T cells co-expressing PD-1 and TIM3 share similar transcriptional and chromatin accessibility profiles, correlating with NFAT-driven secondary activation of NR4A1/2/3 (NUR77/NURR1/NOR1) (21). Here, PDCD1 is linked to neoplasm.