A further contribution of neutrophils to IBD-associated inflammation relies on their ability to secrete several chemokines and cytokines (e.g., CXCL1, CXCL2, and CXCL5, IL-8, IL-1β, and IL-17) that promote the recruitment of other immune cells, such as monocytes, T cells, and NK cells (78). This evidence concerns the gene IL1B and inflammatory bowel disease.