However, the inflammatory role of GBP5 is not restricted to the control of inflammasome, as GBP5 can trigger the expression of numerous pro-inflammatory cytokines and chemokines through an inflammasome-independent mechanism, which is mediated by STAT1 and leads to innate lymphoid cell (ILC) proliferation and, eventually, intestinal inflammation in a DSS mouse model (48). The gene discussed is GBP5; the disease is gastroenteritis.