Multiple classes of traditional antidepressants, such as SSRIs, tetracyclic antidepressants (TeCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs), inhibit the activation of the NLRP3 inflammasome in MDD (Table 3). The gene discussed is NLRP3; the disease is major depressive disorder.