Conversely, osteonecrosis was associated with decreased levels of Myeloid DC %DC, T cell %lymphocyte, CD20 on IgD+ CD38- B cells, CD20 on IgD- CD24- B cells, CD20 on IgD- CD27- B cells, CD3 on EM CD4+ T cell, CD3 on TD CD4+ T cell, CD3 on CD45RA- CD4+ T cell, HVEM on CM CD4+ T cell, HVEM on CD8br T cell, CD28 on secreting Treg, CD28 on resting Treg, CD127 on granulocyte, and CD40 on CD14+ CD16+ monocyte (Figure 3). This evidence concerns the gene CD28 and osteonecrosis.