PLG and periodontitis: Likewise, the previous research on the role of genetics, the assessment of SNPs’ presumed functionality may expose their pathogenic role in inflammatory diseases such as periodontitis and CHD.30–33 The aberrant inflammatory reactivity, determined in part by genetic variants in the loci CDKN2B-AS1 (ANRIL), PLG, CAMTA1/VAMP3, and VAMP8, could explain in part the epidemiological link between periodontitis and cardiovascular diseases.