We focused on the EC seed as a key epicenter in tau propagation and one of the earliest sites of tau accumulation in typical AD.1,24 Among the A− CN group, SFC was highest in the medial-temporal network (step one, closest to EC seed) and propagated to regions of the DMN at step 2 before shifting to sensorimotor regions at steps three to seven. Here, MAPT is linked to Alzheimer disease.