ACOT1, ACOT4, and ACOT6 are acyl-CoA thioesterases that catalyze the hydrolysis of acyl-CoA into FFAs and CoASH, playing key roles in fatty acid metabolism, and their regulation may help alleviate lipid metabolic disorders (Hunt et al., 2012; Pashaj et al., 2013; Sun et al., 2023; Wang et al., 2022; Zhong et al., 2023). The gene discussed is ACOT1; the disease is Disorder of lipid metabolism.