Gentianae Radix et Rhizoma extracts and have demonstrated the ability to reduce the activity of hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase, as well as modulate the bile acid receptor G protein-coupled bile acid receptor 1 (TGR5)/β-arrestin2/NF-κB signaling pathway, thereby delaying the progression of diabetic nephropathy in mice fed a high-fat diet (Ghazanfar et al., 2017; Xi et al., 2020). The gene discussed is GPBAR1; the disease is diabetic kidney disease.