AD, the most prevalent cause of dementia worldwide (Amiri et al., 2025), is a multifactorial neurodegenerative condition characterized clinically by progressive memory loss, cognitive impairment, and behavioral disturbances, and neuropathologically by extracellular deposition of amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein (DeTure and Dickson, 2019; Liu et al., 2024). Here, MAPT is linked to Alzheimer disease.