Beyond neurodegeneration, the observed anti-inflammatory effects of PGG—via inhibition of neutrophil chemotaxis and L-selectin-mediated adhesion (Jang et al., 2013; Kiss et al., 2013; Zhao et al., 2015)—further extend its therapeutic relevance to diseases characterized by aberrant immune responses, such as atherosclerosis and inflammatory bowel disease. Here, SELL is linked to inflammatory bowel disease.