The neuropathological hallmarks of AD include extracellular amyloid-beta (Aβ) deposition and the intracellular accumulation of hyperphosphorylated tau, which together drive synaptic dysfunction and neuronal loss (Murphy and LeVine, 2010; Mondragon-Rodriguez et al., 2012; Chen et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.