An article titled “Visualization and targeting of LGR5+ human colon cancer stem cells” (Shimokawa et al., 2017), which revealed that LGR5 (+) cells serve as cancer stem-like cells (CSCs) in CRC and play an important role in cancer regrowth, had the highest citation bursts in recent years, followed by an article titled “A distinct role for LGR5+ stem cells in primary and metastatic colon cancer” (de Sousa e Melo et al., 2017), which demonstrated that depletion of LGR5 (+) stem cells restricts primary cancer growth. The gene discussed is LGR5; the disease is cancer.