persica-Aq extract at increasing concentrations on p53 levels and Annexin V levels in HepG2, an HCC cell line, over 24 hours was evaluated using an immunocytochemistry assay. A significant increase in p53 and Annexin V expression levels was shown in the extract-treated HepG2 cell groups compared to the untreated control group. S. The gene discussed is TP53; the disease is hepatocellular carcinoma.