VEGF-A is the main angiogenenic signal in AMD and promotes the proliferation of RPE cells and the formation of choroidal neovascularization [22], whereas PEDF, a serine protease inhibitor initially recognized in RPE cells, has now been shown to exhibit anti-angiogenic, neuroprotective, and anti-apoptotic effects [6]. The gene discussed is SERPINF1; the disease is age-related macular degeneration.