ALDH7A1 and epilepsy: One of the best-characterized cases diseases associated with lysine catabolism is pyridoxine-dependent epilepsy (PDE), caused by the loss-of-function mutations of the enzyme α-aminoadipate semialdehyde dehydrogenase (AASADH) (also known as antiquitin, and aldehyde dehydrogenase 7A1, ALDH7A1) (Mills et al., 2006).