CD40LG and cytomegalovirus infection: When HCMV IgG was added into regression models, the dose–response effects seen between increased odds of progression to active TB disease with increased levels of HCMV IgM, HCMV IgG avidity and CRP levels remained (table 3), adding weight to the finding that different measures of HCMV infection and inflammation are independently associated with risk of TB disease progression in this cohort.