CD8A and non-small cell lung carcinoma: In a recent study, whole virome profiling revealed that CMV was the only virus associated with the accumulation of these senescent CD8+ T cells and that a higher proportion of circulating CMV-specific senescent CD8+ T cells, rather than CMV-seropositivity alone, was associated with chemotherapy-induced senescence and poorer outcomes in advanced non-small cell lung cancer [63].