CASP8 and cancer: Finally, the ability of HCMV to inhibit apoptosis in infected cells via the product of the gene UL36, which prevents caspase-8-mediated apoptosis [58], is of notable relevance, caspase-8 mutations being a frequent finding across cancers, including colorectal [59], gastric [60] and head and neck [61] cancers, where they may be prognostic [62].