Conversely, whereas vIL-10 might be anticipated to promote an immune suppressive and tumorigenic microenvironment in HCMV-latent tissues, recent evidence indicates IL-10 is involved in effective anti-tumour immunity, being key to CD8⁣+ T-cell IFNγ-mediated anti-cancer responses [52] and capable of reversing T-cell exhaustion [53]. This evidence concerns the gene IFNG and cancer.