Glioblastoma cells also express inhibitory ligands like Programmed death1-receptor ligand (PD-L1), T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TGIT), T cell immunoglobulin and mucin-domain containing-3 protein (TIM-3), which suppress immune cell activity by engaging their respective receptors on NK and T cells [28–30]. This evidence concerns the gene CD274 and glioblastoma.