KLRC2 and neoplasm: This is interesting because NKG2C-positive NK cells are preferentially found in HCMV-infected individuals [166] and are known to resist the immunosuppressive effects of Tregs [167] and MDSCs in the TME [168], while being highly competent in controlling HCMV infections in virus carriers [32,169], while conferring high toxicity to tumour cells.