Notably, as a pivotal factor in trigeminal neuropathic pain, CGRP's roles extend beyond migraine; for example, in trigeminal neuropathic pain models, epigenetic regulation (via ALKBH5‐mediated m6A modification of Htr3a mRNA) modulates pain signaling, underscoring the multifaceted involvement of trigeminal pathways in pain processing [33]. Here, HTR3A is linked to migraine disorder.