In contrast to other parasite antigens reported in the literature—such as those from Schistosoma mansoni and Trichinella spiralis, which primarily alleviate arthritis by upregulating regulatory T cells (FoxP3+ Tregs) and coordinating anti‐inflammatory cytokine networks to indirectly modulate immune responses tokines [24]—CsCA acts directly on osteoclast precursors and inhibits RANKL downstream signal transduction, demonstrating unique multi‐target osteoprotective properties. The gene discussed is TNFSF11; the disease is arthritic joint disease.