2021). Across the course of life, depression is almost twice as common in females than in males (Culig et al. 2022). This gender disparity in depression rates may be partially explained by differences in BDNF secretion. Females tend to have lower levels of BDNF compared to males (Salari et al. 2024). This reduction in BDNF may impair neurogenesis and contribute to the higher incidence of depression in females. In addition, women are more susceptible to stress and inflammation (Lamichhane et al. 2021), which can further decrease BDNF levels and exacerbate depressive symptoms. This evidence concerns the gene BDNF and major depressive disorder.