Notably, compared with the PD‐L1− tumor group, the upregulated differentially expressed genes (DEGs) in the CD8‐C2‐Texterm subset from PD‐L1+ tumor group included exhaustion‐related genes such as HAVCR2, CXCL13, PDCD1, TIGIT, LAG3, BATF, GNLY, and CTLA4 (Figure 6E; Table S7, Supporting Information). Here, TIGIT is linked to neoplasm.