CD274 and neoplasm: Our previous study revealed that tumor‐derived EVs carry more PD‐L1 than tumor cells, promoting the formation of an immunosuppressive microenvironment and possibly contributing to immunotherapy resistance.[26] Further analysis of the TCGA database revealed a significant positive correlation between the signature of Texterm cells and PD‐L1+ EVs (R = 0.63, P < 0.01, Figure 6G).