Pioneering studies define a four‐stage developmental trajectory for T‐cell exhaustion (Texprog1→Texprog2→Texint→Texterm).[17] To investigate this trajectory, we performed single‐cell mapping, revealing that tumor‐intrinsic PD‐L1 (not immune cell‐derived PD‐L1[44]) primarily governs CD8+ T exhaustion. This evidence concerns the gene CD8A and neoplasm.