To investigate how PD‐L1+ EVs drive Texterm cell generation, we successfully established PD‐LIKO EVs using CRISPR‐Cas9 technology, as verified in our prior studies.[11] Using subcutaneous transplanted tumor and tail vein administration models in mice, we further confirmed that PD‐L1+ EVs drive the differentiation and generation of CD8+ T cells into Texterm cells through a BATF‐mediated transcriptional program. The gene discussed is CD8A; the disease is neoplasm.