The results showed a significant expansion of Texterm (PD‐1+TCF‐1−CD8+ T) cells and PD‐1+CD8+ T cells, along with a concomitant reduction in total CD8+ T cells, in the peripheral blood of HNSCC patients compared to healthy volunteers. Notably, no significant difference was observed in the frequency of Texprog cells (PD‐1+TCF‐1+CD8+ T cells) (Figure 2B,C). This evidence concerns the gene PDCD1 and head and neck squamous cell carcinoma.