Most notably, among the isoforms involved only in translation termination but not in the NMD process, expression of GSPT1‐005 rather than GSPT1‐003 was upregulated in tumors, including BRCA, cervical squamous cell carcinoma, COAD, Esophageal Carcinoma (ESCA), LUAD, lung squamous cell carcinoma, and UCEC tissues when compared to normal tissues. Here, GSPT1 is linked to carcinoma of esophagus.