GSPT1 and acute myeloid leukemia: BRD4 is an epigenetic regulator implicated in AML progression through transcriptional activation of oncogenes.[140] Dual GSPT1/BRD4 degrader DP‐15, exhibited synthetic lethality by dual‐pathway blockade, including transcriptional suppression via BRD4‐MYC axis and translational disruption through GSPT1 degradation.