Especially, all isoforms bind to ribosomal protein large subunit 10, an essential structural cancer gene census of the 60S subunit, which mediates ribosome assembly and coordinates translational elongation.[40] Moreover, all the isoforms of GSPT1 can interact with cereblon (CRBN), a component of the Cullin‐RING ligase 4‐DDB1‐CRBN‐RBX1 (CRL4CRBN) E3 ubiquitin ligase complex,[25] which may indicate that GSPT1 MGDs could degrade all the isoforms of GSPT1 through ubiquitination of E3 ubiquitin ligase complex. This evidence concerns the gene CRBN and cancer.