GSPT1 and acute myeloid leukemia: DP‐15 exerts its antiproliferative effects by promoting early apoptosis and inducing G1 phase arrest, thereby inhibiting cell cycle progression in AML and NHL cells.[141] Besides, the genetic alterations leading to constitutive JAK‐STAT signaling are driving events for several subtypes of ALL, Dual GSPT1/JAK degraders SJ988497 and SJ10542 displayed potent anti‐tumor activity in JAK‐STAT‐driven cell lines by synthetic lethality through dual mechanisms of impaired transcriptional regulation (JAK‐STAT signaling) and disruption of translational termination (GSPT1 degradation).[142, 143]