GSPT1 and cancer: Knockdown of GSPT1 significantly inhibited tumor proliferation, unlocking the potential therapeutic role of GSPT1 for cancer treatment.[19, 20] Furthermore, upregulated GSPT1 expression correlates with poor prognosis in triple‐negative breast cancer.[21] Nevertheless, as a therapeutic “undruggable target”, the precise mechanism of GSPT1 in cancer biology is still unclear, and the effect of targeting GSPT1 in tumors has not been systematically summarized.