Consistent with the ability of MYC to promote immune evasion, GT19630 degraded the negative immune checkpoint inhibitor, B7‐H3.[129] Mechanically, GT19630 significantly induced integrated stress response, abrogated oxidative phosphorylation through inhibition of the TCA cycle, and induced cell death.[47] Other dual GSPT1/MYC degraders by directly targeting the MYC‐GSPT1 axis were also reported to exhibit powerful antitumor activity in MYC‐driven triple‐negative breast cancer and NSCLC.[130]. Here, GSPT1 is linked to non-small cell lung carcinoma.