SIRT1 and endothelial dysfunction: who showed that these vesicles from induced pluripotent stem cell (iPSC)‐derived mesenchymal stem cells were able to mitigate arterial aging in old mice and cultured human ECs, ameliorating endothelial dysfunction, arterial stiffness, and hypertension, likely through regulation of the SIRT1‐AMP‐activated protein kinase (AMPK)‐eNOS pathway, MMPs, and elastase.[213]