LTBP4 and colorectal carcinoma: In our study, none of the tested CRC patients carried loss-of-function variants in LTBP4. Consequently, we are unable to draw any conclusions regarding the role of monoallelic inactivation of LTBP4 through mutation in CRC predisposition. Whether CRC predisposition occurs exclusively through constitutional methylation of LTBP4 CpG island 102 remains to be established.