However, damaging and predicted damaging LTBP4 variant alleles were not enriched in CRC patients overall (4/1264; MAF = 0.32%) when compared to their frequency in population controls (5,542/1,118,062; MAF = 0.47%; source: 590,031 non-Finnish European gnomAD v4.0.0). This evidence concerns the gene LTBP4 and colorectal carcinoma.