BRCA1 and ovarian cancer: Constitutional epigenetic alterations have also been described in BRCA1 and RAD51, predisposing to breast and/or ovarian cancer [9–11]; in DAPK1, associated with increased risk of chronic lymphocytic leukemia [12]; and in KILLIN, identified in Cowden and Cowden-like syndromes in the absence of constitutional PTEN mutations [13].