Furthermore, NDV infection strongly triggers lysosomal membrane permeabilization (LMP) and leads to mitochondria-dependent apoptosis, and importantly, the sialidase activity of the HN glycoprotein induces the deglycosylation and degradation of lysosome-associated membrane protein 1 (LAMP1) and LAMP2 and contributes to NDV-induced LMP and apoptosis, ultimately increasing viral replication in tumour and avian cells [187] (Figure 4). This evidence concerns the gene LAMP1 and neoplasm.