METTL3 and type 2 diabetes mellitus: For example, Dagliflozin inhibits high glucose-induced proliferation, oxidative stress and fibrosis by reducing Mettl3-induced m6A modification in Marcks mRNA [118] Semaglutide inhibits β-cell function through METTL14 signaling and regulation of the gut microbiota in T2D mice [119].