For example, molecular hydrogen activates nuclear factor 2-related factor 2 (NRF2) and its downstream antioxidant enzymes SOD1/2 and anti-oxidative stress protein heme oxygenase 1 (HO-1) to alleviate hypoxia reoxygenation injury and hepatic steatosis in hepatobiliary duct cells [36, 37]. This evidence concerns the gene HMOX1 and fatty liver disease.