Kdm5c plays a critical role in fine-tuning enhancer activity during the process of neuronal maturation, and mutations in Kdm5c contribute to X-linked neurodevelopmental disorders [102, 103] when the knockout mice exhibit a range of abnormalities, including cognitive impairments, deficits in social behaviour, memory problems, increased aggression, and a heightened susceptibility to seizures [103, 104]. This evidence concerns the gene KDM5C and Cognitive impairment.